Norwegian spruce lignans help women manage menopause.

New research establishes EC50 values for Norwegian spruce lignans (HMRlignan-TM) efficacy in managing menopause.

Study confirms 10mg - 30 mg dose for lignan supplement

New research performed by the clinical medicine faculty at the University of Insubria in Italy has added to the body of evidence supporting the use of lignan phytoestrogens to help women manage menopause.

In the study, designed to establish the effective median concentration value (EC50) of Norway spruce-derived lignan, hydroxymatairesinol and its human metabolite enterolactone in comparison to estradiol, experiments confirmed a daily dosage 10 mg - 30 mg as sufficient to raise circulating enterolactone to estrogenically active levels.

Commenting on the significance of the study the lead research pharmacologist, Dr. Marco Cosentino, stated,'The present results support the notion that dietary supplementation with Norway spruce lignans provides a suitable source for endogenous enterolactone which in turn is likely beneficial for several conditions related to estrogen insufficiency (e.g., bone, and cardiovascular disturbances, as well as menopause-associated symptoms), and at the same time devoid of the adverse effects induced by stronger estrogenic agents. Bioavailability studies in humans show that, after oral supplementation with Norway spruce lignans, plasma concentrations of hydroxymatairesinol and enterolactone occur in the sub-microM range, which are below the observed in vitro EC50 (effective median concentration) of hydroxymatairesinol but well above the EC50 of enterolactone. Therefore, in humans, hydroxymatairesinol at the currently recommended doses represent mainly a source of enterolactone, which in turn exerts a mild estrogenic activity.

HMRlignan(TM) is a direct enterolactone precursor dietary supplement standardized to contain 80,000 mg/100 g of lignans. It is a proprietary and patent protected product developed in Finland by Hormos Medical Corporation, and manufactured and marketed worldwide under license by Linnea, Switzerland.

For more information, visit http://hmrlignan.com/html/menopause.htm or e-mail sales@linnea-worldwide.com.